Volume 42, Issue 2OctoberPages The polyvagal theory: Porges Show more https: According to the polyvagal theory, the well-documented phylogenetic shift in neural regulation of the autonomic nervous system passes through three global stages, each with an associated behavioral strategy.
Thus far, I must admit, I have kept the discussion relatively conventional. Anyone who has read my previous blogs may not think so, but compared to what I really believe, everything has taken place close to the middle ground. Time, I believe, to start turning diabetes upside down, give it a good shake, and see what it looks like from a completely different angle.
If not, here it is. To keep things as simple as possible, his view is that the key hormone that drives diabetes is glucagon, not insulin. In addition, we are looking at it the wrong way round.
He is, of course right. Now, stop, stand on your head… Ready, here we go. The critical requirement of human metabolism is to ensure that there is a high enough level of glucose to power the brain. Without sufficient glucose the brains shuts down and dies. Not all the cell types in the brain need glucose and all brain cells can also metabolise ketone bodies, to an extent.
Ketone bodies are synthesized in the liver from fatty acids. However, the bottom line is this. Which means Dual control theory a homeostatic view it is absolutely critical that this does not ever occur. In order to prevent this happening we have a hormone that keeps blood sugar from dropping this low.
It is called Glucagon. It is produced in alpha-cells in the pancreas right next to where insulin is produced. How does it work? Here is a short, standard, explanation from diabetes.
Glucagon plays an active role in allowing the body to regulate the utilisation of glucose and fats. Glucagon is released in response to low blood glucose levels and to events whereby the body needs additional glucose, such as in response to vigorous exercise.
When glucagon is released it can perform the following tasks: Stimulating the liver to break down glycogen to be released into the blood as glucose Activating gluconeogenesis, the conversion of amino acids into glucose Breaking down stored fat triglycerides into fatty acids for use as fuel by cell Of course, this statement from diabetes.
However, I would ask you to review ten of the words again, and think about them for a moment or two. Those ten words, innocent thought they may seem, have been driven by upside down thinking, and represent the exact point where things go wrong. This not deliberate, indeed the concept is so familiar, so unquestioned, that you almost certainly have no idea what I am talking about.
As it stands, we are given to believe that glucagon is the reactive hormone, only produced when blood sugar levels drop. Insulin, on the other hand, is the key hormone, the controller of metabolism and blood sugar levels.
Glucagon only activates to increase blood sugar after insulin or exercise has caused it to fall too far. Which is why we have these ten words: Then try this alterative statement on, and see how it fits. If, however, the glucose levels rise too high, the body produces insulin to counteract the effects Glucagon.
This brings blood sugar back down. Looked at in another way, however, and I have just changed everything. Once you have changed your thinking around this way, it should come as absolutely no surprise to find the following. If you have a mouse, and you destroy its beta-cells insulin producing dells in the pancreas it will become diabetic, and die.
However if you get rid of the glucagon producing cells as well, the animal will not have a high sugar level and will not be diabetic — despite having no insulin at all. It will also appear to be completely healthy.The Dual Center Theory does not explain the long term effects of lesioning of LH and VMH on the control of body weight.
Alternatively, it was suggested that these cerebral nuclei tend to control hunger, satiety and ultimately the body weight through a Set-Point Mechanism (defining an optimal level). Abstract.
CXCR4 is a G-protein-coupled receptor involved in a number of physiological processes in the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated with several diseases, such as HIV, cancer, WHIM syndrome, rheumatoid arthritis, pulmonary fibrosis and lupus.
ANTI-AGING FIREWALLS THE SCIENCE AND TECHNOLOGY OF LONGEVITY. A comprehensive document for the benefit of people interested in living very long healthy lives and who are willing to adapt emerging knowledge personally to do so.
Cybernetics is a transdisciplinary approach for exploring regulatory systems—their structures, constraints, and possibilities. Norbert Wiener defined cybernetics in as "the scientific study of control and communication in the animal and the machine." In the 21st century, the term is often used in a rather loose way to imply "control of any .
In the jawless fish, neural control of the heart is very primitive. Some jawless fish, such as hagfish, rely on circulating catecholamines from diffuse chromaffin tissue to provide excitatory influences on the heart. Jun 14, · The glucostatic theory (dual control theory) is based on the homeostatic view of hunger and satiety.
As we eat, insulin hormones will increase in number in the body to help break down sugars in the food we consumer in order to increase blood glucose levels.